Hematology: AVL’s CBC

All CBCs at AVL are processed in two parts:
1) Automated Analysis
2) Manual differential/ blood smear review

1) Automated Analysis

AVL is currnelty using a Cell-Dyn 3700 which is used in many universities and research facilities. The analyzer is equipped to provide complete blood counts on a variety of species. The Cell-Dyn 3700 analyzes up to 10,000 cells per sample. Four distince light scattering measurements are made on each WBC. (Light scatter analysis: 0°, 10°, 90°, 90° Depolarized)

AVL Hematology Analyzer: Species List

Sheep Dog Pig
Elk Cat Deer
Camel Horse Alpaca
Rabbit Cow Guinea Pig
Hedgehog Goat Raccoon
Woodchuck Llama Skunk
Monkey Ferret Rat
Tiger Hamster Baboon
Buffalo Opossum Leopard
Zebra Mouse Gorilla
Manatee Chimp Aoudad
Seal Lion Whale
Fish Elephant Reptile
Dolphin Giraffe Bird


2) Manual Differential and Blood Smear Review (when certain criteria is observed)

Automated analyzers, like those used at AVL, provide accuracy and reproducibly in the counting and sizing of the cellular components of blood. However, in our experience, no analyzer can replace the manual differential and manual review of the blood smear.

Every day at AVL we review blood smears to find abnormalities that could not be detected by automated analyzers, such as: E.canis inclusions, hemobartonella canis, hemobartonella felis, toxic neutrophils, atypical lymphocytes, microfilaria, mast cells, abnormal RBC morphology: basophilic stippling, acanthocytes, spherocytes etc. Blood smears are prepared and reviewed on all CBCs submitted to AVL.


WBC, RBC, HCT, HGB, erythrocyte indices, platelet count, WBC differential/blood smear review, RBC morphology, WBC morphology, blood parasite screen, reticulocyte % and # when anemia is present.
Pathologist review of abnormal CBC/blood smears at no additional charge when required.